PPARs and Gout

Gout is a type of inflammatory arthritis. Arthritis is a common condition that causes swelling and pain in your joints. It is considered a chronic disease and does not happen once and will usually last your whole life.

Gout usually occurs sudden with no pre-symptoms, sometimes attacks severely which called flares or flare-ups. During the gout occurrence or gout attack, it accompanied by extreme pain, swelling and redness in your joints. Gout attack often happens in the big toe but can affect any your body joints like your knees, elbow, hands or ankles. It is extremely painful and sometimes hard to control, which can be either acute or chronic.

 Differences between acute gout and chronic gout

Acute Gout

• Symptoms only felt during attacks.
• Commonly 1 -3 joints are affected.
• Attacks may last for days to week.

Chronic Gout

• More than one joints is affected and will have more than 2 attacks per year.
• Chronic gout can lead to permanent joint stiffness, deformity and damage.
• Attacks usually happens with short period of time. Attacks might one after another and no breaks/symptoms in between.

Causes of Gout
Gout causes are usually due to the buildup of uric acid in your blood from the breakdown of purines. Certain conditions, such as blood and metabolism disorders or dehydration also makes our body to produce more uric acid. Diets is also associated with gout.

A kidney or thyroid problem, or an inherited disorder, can make it harder for your body to remove excess uric acid.

• Middle aged man or post-menopausal woman
• Genetics
• Eat too much purine-rich foods, such as red meats, fish, mushroom, organ meats’
• Alcohols
• Medications
• Conditions such as high blood pressure, kidney disease, thyroid disease, diabetics, or sleep apnea.

The accumulation of sodium urate crystals within joints leads to gout. The accumulations of uric acid crystals in the joints cause flare-ups and painful inflammation in and around the joints. Typical gout symptoms include intense joint pain, lingering discomfort, swelling, redness, and reduced movement. There are high chances of gout developing into other complication like hyperuricemia, hypertension, hyperlipidemia, coronary disease, diabetes, kidney stone and hardening of arteries of coronary heart disease.

GOUT COMPLICATIONS

What exactly causes high uric acid in our body?

What exactly causes high uric acid in our body?

Uric acid is a natural waste product from the digestion of foods that contain purines. Purines are found in high levels in some foods such as:

• certain meats
• sardines
• dried beans
• beer
• Alcohol
• Shellfish
• Organ meats (liver)

Purines are also formed and broken down in your body. Normally, your body filters out uric acid through your kidneys and in urine. If you consume too much purine in your diet, or if your body can’t get rid of this by-product fast enough, uric acid can build up in your blood.

Uric acid can collect in your body for many reasons. Some of these are:

• diet
• genetics
• obesity or being overweight
• stress

Besides taking in too much high purine foods, it can be also caused of excretion disorder of uric acid. Normally, uric acid passes through liver, and enters bloodstream. Most of it is excreted out of the body through urine or intestines. However, when body cannot function regularly upon excreting uric acid out the body, its results in accumulation of uric acids and leads to gout.

Treatment

Treatment for gout involves medication. Gout medications can be used to treat acute attacks and prevent future attacks. Medications can also reduce your risk of complications from gout, such as the development of tophi from urate crystals deposits.

Lifestyle and home remedies

Medications are often the most effective way to treat acute gout and can prevent recurrent attacks of gout. However, making certain lifestyle changes also are important such as:

1. Limiting alcoholic beverages and drinks sweetened with fruit sugar (fructose)
2. Limiting intake of foods high in purines, such as red meat, organ meat and seafood.
3. Exercising regularly and losing weight. Keeping your body at a healthy weight leaves your risk of gout.

PPARs and GOUT

Peroxisome proliferator-activated receptors are a subgroup of nuclear hormone. As for Crypto PPAR, we have 3 bio-organic component known as PPAR y, PPAR B, and PPAR a.

PPARs known to be effectively treat lupus, gout and rheumatoid arthritis. Especially in reliving acute pain and inflammation.

PPARs has anti-inflammatory properties and effective in inhibiting inflammatory mediators. It works fine in relieving in gout pain and also reduces the swollen toe. The three PPARs receptors are-ligand activated transcription factors belonging to the nuclear hormone receptor superfamily.

PPAR-gamma are effective in treating inflammation. It decreases the inflammatory response of many cardiovascular cells, particularly endothelial cells. PPAR-y has been recognized as playing a fundamental important role in the immune response through its ability to inhibit the expression of inflammatory cytokines and to direct the differentiation of immune cells towards anti-inflammatory phenotypes.

There are findings highlight the genetic impact on the clinical expression of the gouty arthritis phenotype, including arthritis phenotype, including arthritis flares frequently associated with dietary excesses. The nutritional biosensor PPAR-y is a ligand-dependent nuclear receptor and transcription factor that regulates insulin sensitivity, adipocyte differentiation, and glucose homeostasis.

Reactions after consuming Crypto PPARs for Gout

1. The PPARs Gamma in Crypto PPARs aids in the reduction of gout inflammation and pain.

2. Reduction in swollen areas.

3. Might have slight pain in the beginning due to the healing crisis. The body needs to adjust along with the Crypto PPARs reaction. Body aches will start reducing, and swollen toe will reside along the way.

4. Prevent future flare-up.

 Products suggested for Gout disease

ACUTE GOUT

CHRONIC GOUT

Are you a morning person? Reaching for a cup of coffee will be the first thing to do on your list. Some might look for a sandwich, go for cereals or cookies, or go for some form of pastry. As they say, breakfast is the most important meal of the day. The food we eat in the morning will keep us energized throughout the whole day. Thus, the food we eat for breakfast does matter, and here are the best foods that make your day brighter.

1. Banana

Bananas are usually on-the-go fuel for your body, especially before sports/exercise. It is one of the best food to be taken in the morning. Bananas are packed with potassium and fiber. Fiber as its benefit in slowing down the absorption of glucose in the bloodstream. Moreover, it provides a great source of magnesium and vitamin B. It can be a good snack on the go as well.

2. Chia seeds

 Small but mighty! Chia seeds can be good food for steady energy throughout the day. It has an excellent combination of stable energy release, which includes protein, fat, and fiber. Chia seeds can soak fluids and expand as much as 10 times their size. It helps you to feel full for longer periods. They're packed with antioxidants, vitamins, minerals, protein, fat, and fiber.

3. Eggs

An egg is a protein-packed food and provides energy to fuel your day. In addition to being rich in protein, eggs are also rich in leucine, iron, choline, vitamin D, Vitamin B, including B1, B2, B6, and B12, which are essential for energy production. These vitamins help enzyme perform their role in the process of breaking down food for energy. Scrambled, sunny-side up, boiled, fried egg, and no matter how it is prepared, it will provide you with sustained energy.

4. Lentils

Lentils are a good source of nutrients and help to boost energy levels. It is a great and inexpensive source of protein. Lentils are legumes that are rich in carbohydrates and fiber. The fiber in lentils helps to regulate bowel movement and prevent constipation. It promotes delay in stomach emptying and controls the absorption of blood glucose.

5. Seeds

Apart from chia seeds, flaxseeds and pumpkin seeds could also increase your energy level. These seeds are generally high in plant-based omega-3 fatty acids. Fatty acids are also an essential source of stored energy and help your cells functions. Moreover, seeds are a good source of fiber and protein. The fiber in seeds contributes to the nutrients' slow digestion, resulting in a steady, sustained release of energy.

 6. Oatmeal

Oatmeal is a whole-grain cereal that could provide you with lasting energy. It is a low glycemic index food that contains beta-glucan. Beta-glucan is a soluble fiber that forms a thick gel when combined with water. The digestive system delays stomach emptying and glucose absorption into the blood upon forming a thick gel in the digestive system.  Moreover, it is rich in vitamins and minerals that help produce energy, including B vitamins, iron, and manganese. The combination of all these nutrients makes oatmeal a perfect energy food.

7. Dates

Dates! Not known by many but popular during Eid days. Dates are usually dried and have a sweet flavor. It has essential nutrients and a variety of benefits. High in fiber, protein, potassium, magnesium, copper, iron, vitamin B6, and manganese. High in fiber, which is beneficial for preventing constipation and controlling blood sugar control. Moreover, its high in antioxidants, such as flavonoids, carotenoids, and phenolic acid.

Flavonoids: Flavonoids are potent antioxidants that may help to reduce inflammation and have been studied for their potential to reduce the risk of diabetes, Alzheimer's disease, and certain types of cancer.

Carotenoids: Carotenoids are proven to promote heart health and may also reduce the risk of eye-related disorders, such as macular degeneration.

Phenolic acid: Known for its anti-inflammatory properties. Phenolic acid may lower the risk of cancer and heart disease.

Dates are incredibly versatile and make a delicious snack. They are often paired with other foods, such as almonds, nut butter, or soft cheese.

8. Fatty Fish 

Fatty fish such as salmon, tuna, and mackerel are a good source of protein and omega-3. But they provide vitamin B12, which works with folic acid to produce red and white blood cells. Maintaining optimal levels of red blood cells in your body, which energizes your body and increase your metabolism.

9. Hummus

Hummus is made with chickpeas, oils, lemon, and sesame seed paste. The combination of all these ingredients makes it a good source of energy. The chickpeas are the main ingredient, a complex carb, and fiber that the body uses for steady energy.

Moreover, the sesame seed and oils in hummus, contain healthy fats. These ingredients are also helpful in slowing down the absorption of starch and glucose, which avoid blood sugar rise.

You may also enjoy the hummus as a dip for veggies or other dishes such as sandwiches and salads. The meat patty in burgers can also be substituted with hummus patty.

There is a variety of foods that can boost your energy all day. Just get the best foods with carbs, fiber, protein, and healthy fats. These foods listed above can increase your strength, power, and stamina.
Additionally, these foods above not only high in fiber and carbs, but they also contain significant amounts of other nutrients, including vitamins, minerals, and antioxidants. All the foods above have various health benefits. You can always incorporate these foods into your diet.

Covid-19 has been hard for all of us. We were stuck at home for a long time, taking care of ourselves, and trying our best to stay safe. We have been in hibernating mode, resting home, eating away too much, lazing around, snacking at a random time, and sleeping late. No gym, no exercise but we have a plenty of time to make changes to ourselves. Now it is a great time to detox your body, mind, and lifestyle to set yourself. Use all the free times we have to start up a habit and practice it daily to be more active and have an enjoyable life ahead.   

Detox is a hype at the moment and never out of the trend. Here are the few steps to better health and an improved sense of vitality. Make the most out of busy days. Utilize all your free time to shed off all the excess fat and toxins out of the body.

1. Always stay hydrated

Hydration is the best healthy detox you’ll ever give your body. Make sure you drink an adequate amount of water. Drinking the right amount of water will provide you with increased energy, clearer skin, better digestive health, and balanced gut bacteria.

2. Cut your sugar intake

Start by cutting your sugar intake. Don’t be addicted to sugary, carbonated drinks, which only increases dehydration and insulin spikes. High sugar can lead to weight gain (eventually prevent weight loss no matter how hard you try), deplete minerals from your body, stress liver, negatively impact cardiovascular health, and cause sleep problems. 

3. Move your body

Exercising is a form of a healthy detox. Regular exercising helps you to regulate circulation in the blood and lymph system, enhance digestion, reduce tension, lubricate joints, and strengthen your body. People who exercise regularly have fewer toxins in their system because exercise primarily helps regulate and remove the toxins from the body.

4. Decrease your salt intake

For a point of view of some people, detoxing is also about eliminating the excess of water. Consuming too much salt can cause your body to retain excess fluid in the body. This excess fluid buildup can cause bloating and make you uncomfortable. You can detox yourself by reducing salt intake in foods if you find yourself consuming too much salt. 

5. Eat more antioxidants rich foods

Oxidative stress is essentially an imbalance between the productions of free radicals in the body. It eventually leads to a chain reaction that may damage the cells in the body. Eating a diet rich in antioxidants can help your body fight oxidative stress caused by excess free radicals and other toxins that increase your risk of disease.  

6. Get your sleep

Good sleep hygiene is as important as regular exercise and a healthy diet. Consider a sleep reboot where you eliminate caffeine, coffee, tea, alcohol, avoid junk foods, and late meals. Try to ban TV, computer, and smartphone screens for at least two hours before bedtime. 

7. Eat more fruits and vegetables

A colorful variety of fruits and vegetables should be the main focus of your diet along with whole grains, beans, legumes, and small amount of nuts and seeds.  

Swapping out processed foods that lack the nutrients your body needs in favor of more fruits, vegetables, and whole grains will help you feel better, without doing an extreme juice cleanse (Example: dark green vegetables).

8. Other helpful detox tips

• Try out Crypto PPARs– Crypto PPARs are a type of algae that has many nutritional benefits and may enhance the elimination of toxins from your body. Contains a high content of chlorophyll which helps in detox, purifying the blood and the organism, cleanses intestine and aid in elimination, detoxification of the liver, eliminating molds in the body and purify the blood and cleaning it of toxins.

• Eat sulfur-containing foods– Foods high in sulfur, such as onions, broccoli, and garlic, enhance excretion of heavy metals like cadmium.

• Enhance glutathione– Eating sulfur-rich foods strengthen the function of glutathione, a major antioxidant produced by your body that is heavily involved in detoxification.

9. Meditate

Meditation is the best way to cleanse your soul and mind. It helps to lower blood pressure, heart rate, increase and improves concentration, improves clarity, and contribute to peace. 

These are the detox tips to cleanse your body, mind, and soul. Yes, we heard you! About our detoxification system. Our body has its detoxification system, which is thoroughly kidney and liver. Yet, we always need to enhance our body's natural detoxification system and improve overall health by staying hydrated, consume less salt, stay active and exercise, and follow an antioxidant-rich diet.