Home / News / PPARs and Lupus
PPARs and Lupus

PPARs and Lupus

  • Managing lupus
  • Diet for lupus
  • PPARs and Lupus

 

As mentioned, lupus is a complex autoimmune condition with a wide variety of symptoms. As an autoimmune disease, it can affect any part of the body, including tissues and organs. The only best way is to manage lupus and also prevent the flare from occurring. Lupus management and some lifestyle measure can improve a person's quality of life. 

There are no measures to prevent lupus but knowing the triggers that cause flare can help the person with the condition better to be well prepared when they occur.

Get to know lupus flare: https://crypto.com.my/blogs/news/the-disease-of-1000-faces-lupus.

How can I tell if a lupus flare is coming?

Lupus flare most often has some signs and symptoms. We can always prevent the flares or make them less severe if you spot warning signs and seek treatment immediately. These are some symptoms you might get before the flares, such as:

  • Rash
  • Fever
  • Stomach ache
  • Tired
  • Severe dizziness
  • Headache

There is no way to know if a flare will be mild or severe. Mild or moderate flares may cause only a rash or more joint pain. But severe flares can damage organs in the body, including fluid buildup around your heart and kidney disease.

Should I watch over my diet because I have lupus?

Diet and lupus can also be related. There is no specific food to be eaten or to be avoided. Yet, knowing the right food can prevent the triggers or flare. In general, eating a nutritious, well-balanced, and varied diet that contains plenty of fresh fruits and vegetables, whole grains, and moderate amounts of meats, poultry, and fish is good enough.

Adding herbs, supplements, or vitamins to the diet should be discussed with the doctor. As some supplements or herbs may interact or interfere with the effect of lupus medications. Herbs or supplements should never be used to replace medicines prescribed to control lupus symptoms or medication side effects.

Some items have to be eliminated from your diet because of the medications or the damage that lupus has done to specific body parts. Some diets may be altered or modified due to certain damages done to the body by lupus, such as kidney disease, liver damage, muscle pains, or more. Alcohol and meat consumption are always recommended to be in moderation if lupus has damaged your organs. 

PPARs and LUPUS

There is no cure for lupus. Yet, some medications, treatments, and therapies may help to alleviate the symptoms and flare-ups. According to studies, PPARs help to ease the symptoms and also suppress inflammation. It may also help in inhibiting the inflammatory mediators and reverses the organ damages. 

PPARγ, also known as PPAR gamma, plays the most crucial role in suppressing the inflammatory actions caused by lupus. PPAR gamma, which is rich in anti-atherogenic and anti-inflammatory properties, regulates inflammation and immunity. PPARγ regulates the inflammatory signal initiated by activation of CD40, with is essential in the implications of immunological mechanisms in underlying systemic lupus erythematosus. 

Reference: https://pubmed.ncbi.nlm.nih.gov/24456224/

In terms of immunity, PPAR gamma and its ligands are the most critical ones for the modulation of immune cells like monocytes, T cells, NK cells, and inflammatory reactions. Women with systemic lupus erythematosus exhibit a high prevalence of hypertension, endothelial dysfunction, and renal injury. There is a study done on peroxisome proliferator activator receptor β/δ (PPARβ/δ) agonist, ameliorates disease activity and cardiovascular complications in a female mouse model of lupus. The study concluded that pharmacological activation of PPARβ/δ reduced hypertension, endothelial dysfunction, and organ damage in severe lupus, which was associated with reduced plasma anti-double-stranded DNA autoantibodies and anti-inflammatory and antioxidant effects target tissues. The findings identify PPARβ/δ as a promising target for an alternative approach in treating systemic lupus erythematosus and its associated vascular damage.

Reference: https://www.ahajournals.org/doi/full/10.1161/hypertensionaha.116.08655

Besides, as mentioned earlier, one of the robust functions of PPARs is that it rejuvenates cells and supports the healing process of damaged body tissues. PPARs have also been studied with reverse tissue damaging properties. 

Reference: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1386118/

Apart from PPAR gamma, PPAR alpha is also known for its magnificent effects on organ functions. PPAR α activation has conferred additional benefits on endothelial function, kidney function, and anti-inflammation. PPAR α- activators, such as hypolipidemic drugs in fibric acid class, were proven to have therapeutic effects on metabolic syndrome and cardiovascular disease.  

Reference: https://www.hindawi.com/journals/ppar/2010/345098/

The study above focuses on signaling pathways, ligand selectivity, and physio-pathological roles of PPAR in kidney diseases and the therapeutic utility of PPAR modulators in the treatment of diabetes and inflammation-induced nephropathy. As severe, lupus may also lead to kidney necrosis or kidney failure. Knowing the importance of PPAR α is also essential in showing that PPARs help alleviates organ damage and aid in reversing the damage done to the kidney. 

Reference: 

  1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1386118/
  2. https://pubmed.ncbi.nlm.nih.gov/30393147/
  3. https://pubmed.ncbi.nlm.nih.gov/24456224/
  4. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327470/
  5. https://grantome.com/grant/NIH/R01-AR047451-03
  6. https://www.scirp.org/journal/paperinformation.aspx?paperid=76656

In conclusion, all the studies above show how PPARs can help in lupus diseases. The best way to get access to PPARs is by taking supplements which is rich in PPARs. As for Crypto PPARs, it has not only one but contains 3 PPARs which PPARs alpha, PPARs beta, and PPARs gamma. These PPARs have been studied in lupus management, treatment, therapy, organ damage, and healing as above. Thus, it potentially could be the best solution for lupus. 

As for Crypto PPARs, it has 100% natural with no added preservatives, binders, or any other ingredients. It is 100% Chlorella Sorokiniana W87-10. Thus, it won't interfere with lupus medications. Moreover, it is very high in chlorophyll content which benefits the lupus patients who have anemia diseases. Furthermore, it has a chlorella growth factor which is also beneficial in lupus as it aids in cell rejuvenation and cell healing faster and quicker. Thus, it also benefits in replacing the damaged tissues and organs more quickly.